50. "Mike Tyson's Punch-Out!!"
Original release date: October 18, 1987
Platform: Nintendo Entertainment System
When you think of boxing video games, the first one that comes to mind has to be "Mike Tyson's Punch-Out!!" Players took on the role of Little Mac, who fought his way up the ranks to beat the big guy, Mike Tyson, at the end.
The game was re-released in 1990 and billed as just "Punch-Out!!," after Nintendo's license to use Tyson expired. The last battle was replaced by a fictional character, named Mr. Dream. The game was also released for the Wii in 2009.
The game was notoriously hard, however. Not even Tyson can beat himself in the game.