Director - Andrew Davis

In this famous showdown between Richard Kimble (Harrison Ford) - a doctor wrongly accused of murdering his wife - and U.S. Marshal Samuel Gerard (Tommy Lee Jones), Kimble gets the jump on Gerard in the sewers. Instead of shooting the Marshal and making things worse, Kimble pleads his case to him saying, "I didn't kill my wife!" Gerard, with a sober tone and intense look on his face, responds with a simple, but brilliant and ad-libbed, piece of dialog, "I don't care."
The line wasn't part of the script but those three words reinforced to Kimble, and audiences, that it didn't matter to Gerard whether the doctor was guilty or innocent of the crimes for which he was accused. He was going to get his man - no matter what.