DeGeneres and de Rossi bought the estate for $26.5 million in 2012. It was designed by architect Wallace Frost in the 1930s, and its classical style is still intact.
According to the listing, Santa Barbara is sometimes referred to as "the American Riviera" because of its similarity to Europe's well-known region.
"The Villa similarly brings touches of the Old World to the New World," reads the press release announcing the listing.
The garden has a mix of olive and eucalyptus trees.
“It feels ancient, like it’s been there forever. Like that hill was never without the house. This is a home that honors nature, and I love that," DeGeneres said in the release. There is a Roman column dating from 200 B.C. at the bottom of the lawn.
"The surrounding gardens and olive trees are almost as wonderful as the interior. The house truly feels like it was built out of the landscape, rather than plopped on a plot," DeGeneres said.
The main house has six bedrooms and six bathrooms.
Inside, the design is classical, yet also modern. The kitchen has rustic exposed ceiling beams and vintage light fixtures.
The 800-square-foot living room has a library, fireplace, and 18th-century Italian floor tiles. "It’s not overly manicured or tidy. It's not overly precious or perfect. And it's a home that manages to be both spacious and cozy at once," DeGeneres said.
There are plenty of spaces to relax, as well as multiple reading areas.
Most of the rooms have exposed bricks walls made with locally quarried stone.
The formal dining room is simple: "If you think of your home as a canvas — regardless of its style of architecture — you can put anything on it. I tend to keep painting the painting until it's so done, there's nothing left to do. That's when I sell the canvas and buy a new one," DeGeneres said.
Since buying the property in 2012, the couple has added an indoor-outdoor entertaining pavilion.
Known as the "Jordan Hall," this extra area has a large living space with a fireplace, bar, and pool table.
There is a sun room with a view across the pool and garden.
An extra kitchen makes this an easy place to entertain guests outside of the main house.
Outside, there's a large dining terrace with an outdoor kitchen and pizza oven.
The pool overlooks the ocean.
And a sunken tennis court is hidden away on the other side of the garden.