In the film: After an incident with hungry pigs, Hannibal takes Clarice to a secluded lake house, drugs her and has her watch him eat the brain of her sadistic co-worker Krendler. She wakes up and handcuffs herself to him and calls the FBI. He’s about to sever her hand, then the next thing we see is her with both hands intact, and Hannibal on a plane, missing one of his.

In the book: Hannibal tries to brainwash Starling with psychotropic drugs and therapy and eventually succeed. They both eat Krendler’s brain and she offers herself to him. They then run off together to Argentina.