The breakthrough in Rene Russo’s acting career happened in 1992 when she played in the comedy action film Lethal Weapon 3 with Mel Gibson. After that, she did a series of commercially successful films. One of her most notable works was The Thomas Crown Affair (1999) where her screen partner was Pierce Brosnan.

In the 2000s, the actress took a break from her acting career. Her comeback was a triumph: she starred in Nightcrawler (2014) which was critically acclaimed and she got 2 nominations for very prestigious movie awards — a Saturn and a BAFTA. Her most recent role was in 2019 in Avengers: Endgame.