Dr. H. H. Holmes
This guy was an affluent Chicago pharmacist, who purchased a drug store, and began acquiring the properties around and above it, until he owned the entire block. Then he turned it into a hotel for the Chicago Worlds Fair in 1893. But this wasn’t an ordinary hotel, and Holmes wasn’t just a pharmacist.
In fact, he was a sadistic psychopath named Herman Webster Midget, who hired various workmen to build separate parts of his hotel, to his specifications. He’d then fire them before it was complete, and then got someone else to compete it. Only he knew the entire layout.
Inside his hotel, was a horror house of dead ends, rooms with no windows, traps, rooms that were secretly gas ovens, and chutes all over the place to slide bodies into the basement where giant incinerators or pits of acid sat.
He was so good at murdering and disposing of bodies, that there was very little physical evidence to tie him to anything. Eventually, he was caught and convicted, and sentenced to hang. The noose didn’t end up breaking his neck, so he asphyxiated for 15 mins before expiring. Seems fitting.
You forgot Harold Shipman, probably the world's most prolific serial killer and a doctor.