The show began on March 27, 2005, and is still running. The sixteenth season recently premiered. As of today, the production has only 3 of the original main characters (who have worked on the show from day one), having lost the fourth one this last season.

Ellen Pompeo (Meredith Gray), Chandra Wilson (Miranda Bailey), and James Pickens Jr. (Richard Webber) are the characters that we’ve been able to follow throughout the series’ 16 seasons, while Justin Chambers (Alex Karev) announced that he won’t renew his contract, a decision that caused a lot of pain to many fans.