Will Ferrell and John C. Reilly
This comedian duo already has 3 movies together. The very first movie they appeared in together in 2006 was Talladega Nights: The Ballad of Ricky Bobby, Reilly’s character refers to himself as “Dr. Watts.” Interestingly, 12 years later the duo appeared in Holmes & Watson. In between these movies, they acted together in Step Brothers.