Jerusalem, Israel: A blind man at the door of the Ethiopian Chapel, Church of the Holy Sepulchre, Jerusalem. Easter is the most religious and spiritual holiday in the Christian calendar. It commemorates the crucifixion of Jesus Christ in Jerusalem, and his resurrection. Orthodox and Catholic Christians focus their celebrations on Church of the Holy Sepulchre in the Old City of Jerusalem, where they have marked crucifixion, burial and resurrection of Jesus since the fourth century.