"KAIST researchers, led by Professor Kwang-Hyun Cho, have introduced a revolutionary approach to treating colon cancer by reprogramming cancer cells into a normal-like state instead of destroying them. Traditional cancer treatments aim to eliminate cancer cells, but they often lead to resistance, recurrence, and severe side effects due to damage to healthy cells. This new method offers a promising alternative by addressing cancer without causing harm to surrounding tissues.

The research team focused on the concept that during cancer development, normal cells regress along their differentiation pathway. To better understand this process, they developed a digital twin model of the gene network that controls normal cell differentiation. Through simulation analysis, they identified key molecular switches capable of pushing cancer cells back into a normal-like state. When applied to colon cancer cells, these switches successfully reversed their malignant characteristics, a breakthrough confirmed through molecular experiments and animal studies.

This study highlights the potential for "reversible cancer therapy," a novel concept where cancer cells can be reprogrammed rather than eradicated. Unlike conventional treatments that rely on trial-and-error drug discoveries, this approach systematically identifies key targets using computational models. The findings suggest that similar techniques could be applied to other types of cancer, opening new avenues for safer and more effective treatments.

The study, co-authored by Jeong-Ryeol Gong, Chun-Kyung Lee, Hoon-Min Kim, Juhee Kim, and Jaeog Jeon, was published in Advanced Science on December 11."