A 1,000-year-old medicine pouch, likely belonging to a shaman and unearthed in a Bolivian cave, has provided the earliest direct evidence of ayahuasca preparation, a potent hallucinogenic tea. The discovery is significant because the psychoactive plants found within the pouch are not native to the high-altitude region, suggesting the owner either traveled to gather them or had access to a trading network. According to archaeologist Melanie Miller, whose team found the bundle, “This is the first evidence of ancient South Americans potentially combining different medicinal plants to produce a powerful substance like ayahuasca.” This find, which also included tools for grinding and snorting the substances, supports the idea that the use of such powerful plant combinations for psychedelic journeys has ancient roots.