If every city claims to be the "Silicon Valley" of its particular home country, you can guarantee Silicon Valley is the gold standard for tech.

Since 2thinknow defines the region by its largest neighboring city, San Francisco takes the top spot. It is the undeniable epicenter of all things tech, from its gigantic startup culture to its venture capital scene to its population of designers and programmers.

Silicon Valley wins in just about every category because the supply chain of innovation has made its home there, even as smaller contenders claw at the title.