Stealth
This is where things get interesting: In the arena of stealth, the F-22 is head and shoulders above any other operational jet in the world right now.
For perspective, the Su-35's radar cross-section (area visible to radar) is between 1 and 3 square meters, or about the size of a large dinner table. The F-22's radar cross section is about the size of a marble.
As Justin Bronk notes:
Whilst the Su-35 does have the hypothetical capability to detect the F-22 at close ranges using its IRST (Infa-Red Search and Tracking) and potentially the Irbis-E radar, both sensors would have to be cued to focus on exactly the right part of sky to have a chance of generating a target track. By contrast, the F-22 will know exactly where the Su-35 is at extremely long range and can position for complete control of the engagement from the outset with superior kinematics.