There’s a post-apocalyptic version of the gang out there
Not even the Scooby gang can escape the trend of dark and gritty reboots. There’s a monthly comic from DC called Scooby Apocalypse.
In it, Daphne is the lead scientist who’s created Scooby as an experiment gone wrong. Shaggy ends up being Scooby’s trainer, while Scooby is a hyper-intelligent dog who can communicate with humans. Fred and Daphne are a reporter and cameraman who are recruited to the cause.