Alyson Hannigan and Jason Biggs (American Pie)
You can’t go through the greatest comedies in history without mentioning American Pie. The saga introduced a manifold of unforgettable characters such as Stifler, his mother, and the couple made up by Jim (Jason Biggs) and Michelle (Alyson Hannigan), who finally get married in the third part. Part of the cast was reunited in 2019, 2 decades after the premiere of the first film.