Ellen Pompeo as Meredith Grey
First episode (2005): "A Hard Day's Night" (Season 1, Episode 1)
Latest episode (2020): "Put on a Happy Face" (Season 16, Episode 21)
What she's up to now (2020): Of course, Ellen is still on Grey's and has been in a whopping 363 episodes and counting. She's also directed two episodes so far and is a producer on the show.