First episode (2005): "A Hard Day's Night" (Season 1, Episode 1)

Latest episode (2020): "Put on a Happy Face" (Season 16, Episode 21)

What she's up to now (2020): Of course, Ellen is still on Grey's and has been in a whopping 363 episodes and counting. She's also directed two episodes so far and is a producer on the show.

First episode (2005): "A Hard Day's Night" (Season 1, Episode 1)

Latest episode (2020): "Put on a Happy Face" (Season 16, Episode 21)

What she's up to now (2020): Like Ellen, Chandra is one of only three original cast members who are still on the show. Besides playing the iconic Miranda Bailey, Chandra has also directed 21 episodes, including the show's record-breaking episode when it passed ER as the longest-running primetime medical drama.

First episode (2005): "A Hard Day's Night" (Season 1, Episode 1)

Latest episode (2020): "Put on a Happy Face" (Season 16, Episode 21)

What he's up to now (2020): Alongside Ellen and Chandra, James has played Richard Webber in 363 episodes and counting. Besides starring on Grey's, James also reprised his role from Roseanne on The Connors.

First episode (2005): "A Hard Day's Night" (Season 1, Episode 1)

Last episode (2020): "Leave a Light On" (Season 16, Episode 16)

What he's up to now (2020): Justin technically made his last onscreen appearance in 2019, and only his voice appeared in Alex's farewell episode in 2020. Justin made the decision to leave Grey's during Season 16 as he looked to "diversify [his] acting roles and career choices."

First episode (2005): "A Hard Day's Night" (Season 1, Episode 1)

Last episode (2015): "How to Save a Life" (Season 11, Episode 21)

What he's up to now (2020): After leaving the show, Patrick went on to star in Bridget Jones's Baby in 2016. Now he stars in the TV series Devils, which premiered last year in Europe.

First episode (2005): "A Hard Day's Night" (Season 1, Episode 1)

Last episode (2014): "Fear (of the Unknown)" (Season 10, Episode 24)

What she's up to now (2020): Sandra currently stars on the critically acclaimed series Killing Eve as Eve Polastri. Her work on the show earned her a 2019 Golden Globe Award for Best Actress in a TV Series, Drama.

First episode (2005): "A Hard Day's Night" (Season 1, Episode 1)

Last episode (2010): "I Like You So Much Better When You're Naked" (Season 6, Episode 12)

What she's up to now (2020): After leaving Grey's, Katherine starred in a number of movies, including Life as We Know It and One for the Money. She also joined the cast of Suits for the final two seasons. In 2020 she's expected to star in Netflix's Firefly Lane opposite Sarah Chalke.

First episode (2005): "A Hard Day's Night" (Season 1, Episode 1)

Last episode (2009): "Now or Never" (Season 5, Episode 24)

What he's up to now (2020): After Grey's, T.R. appeared in several episodes of The Good Wife, and he rejoined the ShondaLand family in the short-lived series The Catch. Most recently, he starred in Genius: Einstein and Genius: Picasso. He'll appear in the upcoming limited series A Higher Loyalty opposite Jeff Daniels, Holly Hunter, and Brendan Gleeson, among others.

First episode (2005): "A Hard Day's Night" (Season 1, Episode 1)

Last episode (2014): "We Are Never Ever Getting Back Together" (Season 10, Episode 22)

What he's up to now (2020): Although he made his last series regular appearance in 2007, Isaiah returned for one episode of Grey's in 2014 as part of Cristina's final arc. After leaving the show, Isaiah went on to star in The 100 as Thelonious Jaha.

First episode (2005): "Who's Zoomin' Who?" (Season 1, Episode 9)

Last episode (2012): " If/Then" (Season 8, Episode 13)

What she's up to now (2020): Of course, Kate went on to star in Private Practice from 2007 to 2013 while still appearing in Grey's episodes. Since leaving the Grey's Anatomy universe, Kate has appeared in 13 Reasons Why, The Umbrella Academy, Girls Trip, and numerous other TV shows and movies. Also, she recently celebrated Addison's iconic first episode, which first aired 15 years ago.

First episode (2005): "A Hard Day's Night" (Season 1, Episode 1)

Last episode (2019): "Blood and Water" (Season 15, Episode 16)

What she's up to now (2020): After Grey's, Kate notably went on to star in Scandal as Vice President Sally Langston. She also appeared on Veep, The Good Wife, and, most recently, Supergirl. Although Ellis died during Season 3, Kate has since made several appearances on Grey's.

First episode (2006): "What Have I Done to Deserve This?" (Season 2, Episode 19)

Last episode (2016): "Family Affair" (Season 12, Episode 24)

What she's up to now (2020): After leaving Grey's, Sara went on to star in Madam Secretary as Kat Sandoval, and she voiced Queen Miranda on Sofia the First.

First episode (2006): "Yesterday" (Season 2, Episode 18)

Last episode (2012): "Remember the Time" (Season 9, Episode 2)

What he's up to now (2020): Eric went on to star in The Last Ship as Tom Chandler from 2014 to 2018. Currently, he plays Cal Jacobs on Euphoria.

First episode (2006): "Begin the Begin" (Season 2, Episode 13)

Last episode (2009): "Here's to Future Days" (Season 5, Episode 23)

What he's up to now (2020): Jeffrey went on to appear in The Good Wife before landing the role of Negan on The Walking Dead. Also, you can currently catch Jeffrey on Friday Night In With the Morgans with his wife, Hilarie Burton.

First episode (2007): "Testing 1-2-3" (Season 3, Episode 24)

Last episode (2012): "Flight" (Season 8, Episode 24)

What she's up to now (2020): Since 2015, Chyler has starred as Alex Danvers on Supergirl.

First episode (2008): "Dream a Little Dream of Me: Part 1" (Season 5, Episode 1)

Latest episode (2020): "Put on a Happy Face" (Season 16, Episode 21)

What he's up to now (2020): Of course, Kevin is still playing Owen and has appeared in 283 episodes. Besides Ellen, Chandra, James, and Justin, Kevin has appeared in the most episodes. He has also directed 27 episodes of Grey's.

First episode (2009): "Wish You Were Here" (Season 5, Episode 11)

Last episode (2018): "All of Me" (Season 14, Episode 24)

What she's up to now (2020): Jessica is scheduled to appear in the Netflix holiday movie Holidate and in the film Dear Zoe opposite Sadie Sink, Justin Bartha, and Theo Rossi.

First episode (2009): "Invasion" (Season 6, Episode 5)

Latest episode (2020): "Put on a Happy Face" (Season 16, Episode 21)

What he's up to now (2020): Of course, Jesse is still on Grey's playing Jackson Avery, and he's directed three episode. He also appeared on Hulu's Little Fires Everywhere this year.

First episode (2009): "Invasion" (Season 6, Episode 5)

Last episode (2018): "All of Me" (Season 14, Episode 24)

What she's up to now (2020): Since leaving, Sarah has starred in several holiday TV movies, including Christmas Pen Pals and Twinkle All the Way.

First episode (2009): "New History" (Season 6, Episode 9)

Latest episode (2020): "Put on a Happy Face" (Season 16, Episode 21)

What she's up to now (2020): After leaving Grey's at the end of Season 8, Kim returned as a series regular during Season 15 and is still on the show.

First episode (2010): "State of Love and Trust" (Season 6, Episode 13)

Latest episode (2020): "Sing It Again" (Season 16, Episode 20)

What he's up to now (2020): Currently, Jason stars on Station 19 and still makes plenty of appearances on Grey's Anatomy.

First episode (2010): "Superfreak" (Season 7, Episode 3)

Latest episode (2020): "Put on a Happy Face" (Season 16, Episode 21)

What she's up to now (2020): Alongside her work on Grey's, Caterina played Amelia on Private Practice from 2010 to 2013 — between the two shows, she's actually appeared as Amelia in 211 episodes and counting.

First episode (2012): "Going, Going, Gone" (Season 9, Episode 1)

Latest episode (2020): "Put on a Happy Face" (Season 16, Episode 21)

What she's up to now (2020): Of course, Camilla is still playing Jo on Grey's and has appeared in 189 episodes and counting — in fact, that's more than Katherine Heigl or T.R. Knight ever appeared in.

First episode (2014): "Everything I Try to Do, Nothing Seems to Turn Out Right" (Season 10, Episode 23)

Latest episode (2020): "Put on a Happy Face" (Season 16, Episode 21)

What she's up to now (2020): Of course, Kelly is still playing Maggie on Grey's and has now appeared in 144 episodes and counting.

First episode (2005): "A Hard Day's Night" (Season 1, Episode 1)

Latest episode (2020): "Put on a Happy Face" (Season 16, Episode 21)

What she's up to now (2020): BokHee has appeared in 257 episodes of Grey's and counting. In real life, she is a surgical nurse too.