Kate Burton as Ellis Grey
First episode (2005): "A Hard Day's Night" (Season 1, Episode 1)
Last episode (2019): "Blood and Water" (Season 15, Episode 16)
What she's up to now (2020): After Grey's, Kate notably went on to star in Scandal as Vice President Sally Langston. She also appeared on Veep, The Good Wife, and, most recently, Supergirl. Although Ellis died during Season 3, Kate has since made several appearances on Grey's.