Sara Ramirez as Callie Torres
First episode (2006): "What Have I Done to Deserve This?" (Season 2, Episode 19)
Last episode (2016): "Family Affair" (Season 12, Episode 24)
What she's up to now (2020): After leaving Grey's, Sara went on to star in Madam Secretary as Kat Sandoval, and she voiced Queen Miranda on Sofia the First.