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Sara Ramirez as Callie Torres

First episode (2006): "What Have I Done to Deserve This?" (Season 2, Episode 19)

Last episode (2016): "Family Affair" (Season 12, Episode 24)

What she's up to now (2020): After leaving Grey's, Sara went on to star in Madam Secretary as Kat Sandoval, and she voiced Queen Miranda on Sofia the First.

 

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“Grey’s Anatomy” Cast 15 Years Ago And Now
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