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Eric Dane as Mark Sloan

First episode (2006): "Yesterday" (Season 2, Episode 18)

Last episode (2012): "Remember the Time" (Season 9, Episode 2)

What he's up to now (2020): Eric went on to star in The Last Ship as Tom Chandler from 2014 to 2018. Currently, he plays Cal Jacobs on Euphoria.

 

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“Grey’s Anatomy” Cast 15 Years Ago And Now
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