Patrick Dempsey as Derek Shepherd
First episode (2005): "A Hard Day's Night" (Season 1, Episode 1)
Last episode (2015): "How to Save a Life" (Season 11, Episode 21)
What he's up to now (2020): After leaving the show, Patrick went on to star in Bridget Jones's Baby in 2016. Now he stars in the TV series Devils, which premiered last year in Europe.