Justin Chambers as Alex Karev
First episode (2005): "A Hard Day's Night" (Season 1, Episode 1)
Last episode (2020): "Leave a Light On" (Season 16, Episode 16)
What he's up to now (2020): Justin technically made his last onscreen appearance in 2019, and only his voice appeared in Alex's farewell episode in 2020. Justin made the decision to leave Grey's during Season 16 as he looked to "diversify [his] acting roles and career choices."