Alfred Molina gave his face to Doctor Octopus that was one of the main antagonists of Spider-Man. This was the role that made him famous for many people. But the actor has more than 200 films and TV series, some of which are iconic, like Chocolat, Frida, Identity.
At the beginning of his career, Molina appeared in Raiders of the Lost Ark where he played the part of Satipo.
Melissa McCarthy has taken over the Cathy Bates roles in this generation.