Ender’s Game (2013)
This film didn’t lose nearly as much money as the other films here, but it makes complete sense that a studio would spend a lot of money on it. Ender’s Game is an incredibly popular science fiction book, and when you get Harrison Ford in an adaptation of it, you damn well better spend some fucking money.
They spent $110 million, but it only made $125 million back. Not nearly as massive a loss as the other films here, but the lost potential, especially when you consider the source material they were working with, is definitely a loss.