Tom Hanks and Meg Ryan
Tom Hanks and Meg Ryan also co-starred in the 1993 film, Sleepless in Seattle.
Jake Gyllenhaal and Anne Hathaway
Channing Tatum and Jenna Dewan
Clive Owen and Julia Roberts
Paul Rudd and Reese Witherspoon
Brad Pitt and Cate Blanchett
Ben Affleck and Jennifer Lopez
Bradley Cooper and Jennifer Lawrence
Keanu Reeves and Charlize Theron
Matthew McConaughey and Kate Hudson
Adam Sandler and Drew Barrymore
Adam Sandler and Drew Barrymore also starred in the 2004 film, 50 First Dates.
Jason Segel and Emily Blunt
Ryan Gosling and Emma Stone
Ryan Gosling and Emma Stone also starred in the 2013 film, Gangster Squad.
Tom Cruise and Cameron Diaz
Hugh Jackman and Scarlett Johansson
Richard Gere and Julia Roberts
Keanu Reeves and Sandra Bullock
Paul Rudd and Jennifer Aniston
Tom Hanks and Julia Roberts
Leonardo DiCaprio and Kate Winslet