Many well-known actors were considered for the role of charismatic Captain Jack Sparrow. The scriptwriter himself wanted him to be played by Hugh Jackman, but the studio had its eyes set on Matthew McConaughey because of his resemblance to Bert Lancaster. Later, however, Jim Carrey was offered the role, but the actor had to turn it down due to filming Bruce Almighty.

In the end, Walt Disney Pictures hired Johnny Depp, who at the time was interested in starring in a family movie.