Jenna Ortega’s first role as the vice president’s daughter in Iron Man 3 in 2013 vs. Jenna as Wednesday in Wednesday.
Nominated for: Outstanding Lead Actress in a Comedy Series
Jason Segel’s first role as Nick in Freaks and Geeks in 1999 vs. Jason as Jimmy in Shrinking.
Nominated for: Outstanding Lead Actor in a Comedy Series
Kieran Culkin’s first role as Fuller McCallisterin Home Alone in 1990 vs. Kieran as Roman in Succession.
Won for: Outstanding Lead Actor in a Drama Series
Pedro Pascal’s first notable role as Eddie in Buffy the Vampire Slayer in 1999 vs. Pedro as Joel in The Last of Us.
Nominated for: Outstanding Lead Actor in a Drama Series
Bella Ramsey’s first role as Lyanna in Game of Thrones in 2016 vs. Bella as Ellie in The Last of Us.
Nominated for: Outstanding Lead Actress in a Drama Series
Christina Applegate’s first big role as Kelly in Married… with Children in 1987 vs. Christina as Jen in Dead to Me.
Nominated for: Outstanding Lead Actress in a Comedy Series
Jeremy Allen White’s first role as Jeremy in Law & Order in 2007 vs. Jeremy as Carmy in The Bear.
Won for: Outstanding Lead Actor in a Comedy Series
Ayo Edebiri’s first notable role as Hattie in Dickinson in 2021 vs. Ayo as Syd in The Bear.
Won for: Outstanding Supporting Actress in a Comedy Series
Ebon Moss-Bachrach’s first notable role as a college boy in Law & Order: Criminal Intent in 2001 vs. Ebon as Richie in The Bear.
Nominated for: Outstanding Supporting Actor in a Comedy Series
Jennifer Coolidge’s first role as Jodi in Seinfeld in 1993 vs. Jennifer as Tanya in The White Lotus.
Won for: Outstanding Supporting Actress in a Drama Series
Aubrey Plaza’s first role as an NBC Page in 30 Rock in 2006 vs. Aubrey as Harper in The White Lotus.
Nominated for: Outstanding Supporting Actress in a Drama Series
Melanie Lynskey’s first role as Pauline in Heavenly Creatures in 1994 vs. Melanie as Shauna in Yellowjackets.
Nominated for: Outstanding Lead Actress in a Drama Series
Tyler James Williams’ first notable role as Tyler on Sesame Street in 2000 vs. Tyler as Gregory in Abbott Elementary.
Nominated for: Outstanding Supporting Actor in a Comedy Series
Natasha Lyonne’s first role as Opal in Pee-wee’s Playhouse in 1986 vs. Natasha as Charlie in Poker Face.
Nominated for: Outstanding Lead Actress in a Comedy Series
Nick Offerman’s first role as Rog on ER in 1997 vs. Nick as Bill in The Last of Us.
Won for: Outstanding Guest Actor in a Drama Series
Lizzy Caplan’s first role as Sara in Freaks and Geeks vs. Lizzy as Libby in Fleishman Is In Trouble.
Nominated for: Outstanding Lead Actress in a Limited or Anthology Series or Movie
Matthew Macfadyen’s first role as Hareton in Wuthering Heights in 1998 vs. Matthew as Tom in Succession.
Won for: Outstanding Supporting Actor in a Drama Series
Sheryl Lee Ralph’s first notable role as Linda in To Sleep with Anger in 1990 vs. Sheryl as Barbara in Abbott Elementary.
Nominated for: Outstanding Supporting Actress in a Comedy Series