Rachel McAdams and Ryan Gosling
Although they made one of the most iconic love stories in recent history, director Nick Cassavetes revealed that they didn’t have very great chemistry. On the 10th anniversary of their film, he said they didn’t get along at all, and at one point the relationship got so bad that Gosling asked to have McAdams removed from the set and for him to bring in another actress to read lines with him. They ended up going into a room with a producer and hashed it out, which must have worked pretty well since they dated for a few years.