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Many pure dogs suffers of inbreeding and a weak gene pool. By mixing races, you mix things up. The negative: They maybe don't look as good as pure races :P
At least this was the case with our dog, a mix. Lived to be almost 16, few to none health problems except at the end, very good with people.
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My two are naughty, friendly, healthy and intelligent. No defects in these two.
#18 wow, the schnoodle looks kind of like an otter!