John Travolta as Edna Turnblad in Hairspray
Tom Hardy as Al Capone in Capone
Ben Kingsley as Mahatma Gandhi in Gandhi
Renée Zellweger as Judy Garland in Judy
Demi Moore as Jordan O’Neil in G.I. Jane
Charlize Theron as Marlo Moreau in Tully
Steve Carell as John du Pont in Foxcatcher
Rooney Mara as Lisbeth Salander in The Girl with the Dragon Tattoo
Tom Cruise as Les Grossman in Tropic Thunder
Nicole Kidman as Virginia Woolf in The Hours
Matthew McConaughey as Kenny Wells in Gold
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Same can be said for Matthew McConaughey's role in "Dallas Buyers Club". A role that required him to physically transform months ahead of principle photography.
Also, how in the world this post completely ignored Christian Bale's drastic physical transformations for several roles he's played, but OH! Demi shaves her head and BAM! She's on the list. lol
Yes. I intended to comment on "Monster". She was masterful in that role.