Ellen Pompeo on Friends
Mariska Hargitay on Seinfeld
George Clooney on Friends
Bob Odenkirk on Seinfeld
Denise Richards on Seinfeld and Friends
Courteney Cox as on Seinfeld
Rebecca Romijn on Friends
Brad Garrett on Seinfeld
Sarah Silverman on Seinfeld
Leah Remini on Friends
Bryan Cranston on Seinfeld
Debra Messing on Seinfeld
Jon Lovitz on Seinfeld and Friends
Reese Witherspoon on Friends
Molly Shannon on Seinfeld
James Spader on Seinfeld
Teri Hatcher on Seinfeld
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Exactly, many were popular before being on these shows. George Clooney? Jon Lovitz? Bryan Cranston? C'mon
Teri Hatcher was playing as Lois Lane at the same time as Seinfeld, "Lois & Clark: The New Adventures of Superman," made her a star.
James Spader was in "Pretty in Pink," "Wall Street," and "Sex, Lies, and Videotape" before Seinfeld even aired.
I could go on but hopefully you get the point. A lot of known actors appeared in TV shows as guest actors for the fun of it because they enjoyed watching the show.